Garry Shandling stars as himself, a neurotic, sardonic stand-up comedian who just happens to be aware he is a sitcom character. Garry spends just as much time interacting with the studio audience as he does the regular cast members, performing monologues and show-closing summations of the episode's events. However, everyone knows they're on TV, not just Garry; and the audience (itself a character) is often involved in the storyline.
Comic Garry Shandling moves into Vanna White's former condominium, has his furniture stolen and makes a date with a beautiful cable installer.
Garry baby-sits Pete and Jackie's son, Grant.
Garry throws a surprise birthday party for his mother that gives her a heart attack, so he seeks solace from Father Guido Sarducci.
Grant is made a social outcast when his father bungles a foul ball at a Dodgers game.
Garry is seduced by Mrs. Robertson, but he's in love with her daughter.
Garry's attempt to focus the entire episode on contest winner Jodi Jones goes awry when Nancy's nymphomaniac friend arrives for a visit.
