Dexter, a boy-genius with a secret laboratory, constantly battles his sister Dee Dee, who always gains access despite his best efforts to keep her out, as well as his arch-rival and neighbor, Mandark.
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Mandark Astronomanov, a new student at Dexter's school, seems to be superior to Dexter academically. Mandark forces Dexter to shut down his lab so that Mandark's lab can gain more power. However, with the help of Dee Dee, Dexter manages to destroy Mandark's lab.
Monkey encounters Simion, an intelligent anthropomorphic chimpanzee who seeks vengeance on humans for turning him into his current state.
Banned from watching a late-night movie due to his young age, Dexter uses his technology to artificially grow into adulthood, but Dee Dee tampers with his machine, causing Dexter to turn into an old man.
Dee Dee and her friends, Lee Lee and Mee Mee, enter Dexter's lab and wreak havoc. Dexter clones himself to stop them, but the girls too make clones of themselves.
Monkey's birthday party is interrupted by Barbequor an intergalactic villain who plans to eat the planets, and his sidekick, the Silver Spooner.
Rerun of "Dexter's Laboratory", the first "What a Cartoon!" pilot.
